Epidermal Dendritic Cells Induce Potent Antigen-Specific CTL-Mediated Immunity

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity

Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential immunogens for the induction of specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histoco...

Brief Definitive Report Peptide-pulsed Dendritic Cells Induce Antigen-specific, CTL-mediated Protective Tumor Immunity

Cytotoxic T lymphocytes (CTLs) are a critical component o f the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential imrnunogens for the induction o f specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable o f priming CTL responses in vivo. Here we show that major his...

Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity.

In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine colon carcinoma system in syngeneic C57BL/6 mice, we have evaluated the efficacy of bone marrow-derived dendritic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine. Anti-idiotype 3H1 mimics a distinct and specific epitope of CEA and can generate anti-CEA immunity in mice, rabbits, monkey...

Dendritic cells efficiently induce protective antiviral immunity.

Cytotoxic T lymphocytes (CTL) are essential for effective immunity to various viral infections. Because of the high speed of viral replication, control of viral infections imposes demanding functional and qualitative requirements on protective T-cell responses. Dendritic cells (DC) have been shown to efficiently acquire, transport, and present antigens to naive CTL in vitro and in vivo. In this...

Innate and Adaptive Immunity of Antigen-Presenting Cells at the Crossroads Human Dendritic Cells: Potent